Do you mean v21 in general or build 49 in particular?
v21 no longer uses ONIG.DLL and 4CONSOLE needs it. I have attached ONIGDLL.ZIP. Puttting the extracted ONIG.DLL in the same directory as TCC.EXE may fix the problem. If you have TCMD v20 (maybe earlier) you may already have an ONIG.DLL.
If it's not due to a missing ONIG.DLL ... Rex, can you help out? ... any idea what dll or function might me missing on my Win7/x86 system? ... if not, can you zip TCC.EXE and TAKECMD.EXE and email them to me (I'll need to unzip them on Win7/x86 and inspect them with DUMPBIN).